the 50mm 1.8 isn't the best long range lens. it does a great job for portraits and stuff.
however, i have not shot mine at night, so maybe with darker colors, sharpness may not be an issue.
as for focusing, do you have a camera with live view? if so, you can digitally zoom to 10x and it will help with any focusing either manual or auto focus. Also try to find something with a strong line of contrast and aim at it.
it may also help to set the camera to a single point auto focus and just aim that single point at an area easiest for the camera to pick up, especially since the middle point is the strongest
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