Obviously the settings for M1 and M2 are personal preference but I use mine as follows.
When I start the car (neither M1 nor M2 selected) I have everything in Comfort/Efficient mode and least aggressive shift modes.
I use M1 for a "slight bump" in performance - Sport Steering, Sport Throttle, Comfort Suspension, D2 shifts, DSC normal, no change in the HUD.
I use M2 for more aggressive Driving - Sport + Steering, Sport + Throttle, Sport Suspension, D3 Shift mode, DSC normal, M HUD mode.
I don't use Sport + Suspension Mode street driving and I don't use MDM or DSC OFF for typical street driving. If there are rare circumstances where I want MDM or Sport + suspension modes I can always reach down and press the button. Also, it is very easy to switch transmission modes by just hitting the steering wheel paddles to take it from D to M (S). Of course, your mileage may vary....
